Piracetam lipofuscin

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Piracetam lipofuscin

Posted Feb 28, 2016 by Admin

Piracetam was found to markedly decrease the formation of neuronal lipofuscin. Whatever the functional implications of this pigment, its reduction in piracetam-treated animals might be related either to a protective effect on the intraneuronal membranous system or to an antioxidant property of this molecule. In addition, it was also found that alcohol withdrawal does not reverse these changes. On the contrary, most of the alterations observed during alcohol consumption worsen as happens with the increased lipofuscin formation.

Thus, using our model of alcohol feeding and withdrawal, we decided to examine the effects of different drugs said to offer neuronal protection during CNS degenerative processes. The action of piracetam, a cyclic derivate of GABA and commonly used as a nootropic agent, was tested.

Keywords: Lipofuscin; Neurons; Alcohol; Withdrawal; Piracetam There is a growing body of evidence indicating that chronic alcohol consumption induces morphological changes in the central nervous system (CNS) similar to those observed during brain senescence, including an increased formation of lipofuscin.

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Abstract Send to: See comment in PubMed Commons below. Alcohol Clin Exp Res. 1991 Oct;15(5 834-8. Paula-Barbosa MM 1, Brando F, Pinho MC, Andrade JP, Madeira MD, Cadete-Leite A. Author information 1Department of Anatomy, Porto Medical School, Portugal.

Abstract There is a growing body of evidence indicating that chronic alcohol consumption induces morphological changes in the central nervous system (CNS) similar to those observed during brain senescence, including an increased formation of lipofuscin.

Piracetam was found to markedly decrease the formation of neuronal lipofuscin. Whatever the functional implications of this pigment, its reduction in piracetam-treated animals might be related either to a protective effect on the intraneuronal membranous system or to an antioxydant property of this molecule.

PMID : 1755517 PubMed - indexed for MEDLINE. Publication Types, MeSH Terms, Substances Publication Types Research Support, Non-U.S. Gov't. MeSH Terms Alcohol Withdrawal Delirium/pathology Alcoholism/pathology Animals. Cerebellum/drug effects Cerebellum/pathology Cytoplasmic Granules/drug effects Cytoplasmic Granules/ultrastructure.