Piracetam cochrane review

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Piracetam cochrane review

Posted Feb 28, 2016 by Admin

Top of page Abstract Plain language summary Rsum scientifique. Rsum simplifi Laiki saetak Evidence for the efficacy of piracetam for dementia or cognitive impairment is inadequate for clinical use but sufficient to justify further research.Dans les donnes limites disponibles, il n'a t observ aucune diffrence significative entre les groupes sous traitement et les groupes sous placebo en termes de cognition (mmoire immdiate, visuospatiale, Mini-Examen de l'Etat Mental (MEEM retard de la mmoire ou de la parole de dpendance ou. Some of the studies suggested there may be some benefit from piracetam but overall the evidence is not consistent or positive enough to support its use for dementia or cognitive impairment.

Nous avons prvu de procder des analyses de sensibilit pour dterminer si les tudes mdiocres en termes de critre de qualit affectaient les rsultats. Le laboratoire pharmaceutique commercialisant le piractam n'a pas dvoil les rsultats de plusieurs essais non publis.Critres de slection Tous les essais en double aveugle, randomiss, non biaiss dans lesquels le traitement au piractam tait administr pendant plus d'une journe et compar un placebo chez des personnes atteintes de dmence du type Alzheimer, de dmence vasculaire, de dmence mixte vasculaire et.

The evidence indicates a need for further evaluation of piracetam. Read the full abstract. Background: Piracetam is a drug that may enhance memory and other intellectual functions, but its usefulness in treating dementia is uncertain.Global impression of change (GIC) was the only outcome for which pooling of data was possible, involving only four studies. There was evidence of heterogeneity in the results, Chi2 test 19.17 (df 3, P 0.001).

Notes de traduction En novembre 2000, le bureau du CDCIG a excut nouveau la stratgie de recherche, mais aucune nouvelle tude n'a t identifie pour inclusion. Deux autres publications en double de l'tude de Israel 1994 ont t identifies et 14 autres nouvelles tudes ont.Rsultats principaux 24 tudes ont t incluses, avec 11 959 participants au total. De nombreuses tudes taient croises et les donnes de premire phase n'taient pas disponibles ou ne pouvaient pas tre extraites.

Les preuves indiquent un besoin d'valuation supplmentaire du piractam. Top of page Abstract Plain language summary Rsum scientifique Rsum simplifi Laiki saetak Les preuves de l'efficacit du piractam contre la dmence et les autres troubles cognitifs sont inadquates pour un usage clinique, mais suffisantes pour.Authors' conclusions: Published evidence does not support the use of piracetam in the treatment of people with dementia or cognitive impairment. Although effects were found on global impression of change, no benefit was shown by any of the more specific measures of cognitive function.

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Conclusions des auteurs Les preuves publies ne militent pas en faveur de l'utilisation du piractam dans le traitement des personnes atteintes de dmence ou d'autres troubles cognitifs. Bien que des effets aient t observs sur l'impression de changement globale, aucune des mesures plus spcifiques de.This estimate was derived from completers rather than from an intention-to-treat analysis as relevant data could not be extracted from the reports. In the limited data available, no significant differences were found between treatment and placebo groups for cognition (immediate memory, visuospatial, Mini Mental Status.

The large volume of unpublished and untraceable data not available to the review authors raises the possibility of publication bias.Nous avons identifi une autre revue effectue par des employs et des consultants du groupe pharmaceutique UCB Pharma (Waegemans 2002) qui incluait des donnes issues d'tudes non publies qui n'avaient pas t mises la disposition des auteurs de la revue Cochrane.

Ces tudes ont t values par un seul auteur de la revue (JGE). Aucun changement substantiel n'a t apport au texte de la revue. En mai 2001, la section contexte du rsum a t ajoute et la principale section contexte a t rcrite.Le volume important de donnes non publies et de donnes dont l'origine est introuvable, dont les auteurs de la revue n'ont pas pu disposer, soulve la possibilit d'un biais de publication.

Recueil et analyse des donnes Deux auteurs de cette revue ont extrait des donnes d'tudes remplissant les critres d'inclusion de manire indpendante. Nous avons utilis une analyse en intention de traiter lorsque cela tait faisable et avons regroup les tudes lorsque cela tait appropri.Certaines de ces tudes suggraient que le piractam pouvait prsenter un certain bnfice, mais, globalement, les preuves ne sont pas suffisamment cohrentes ou catgoriques pour soutenir son usage contre la dmence ou les autres troubles cognitifs.

The odds ratio (OR) for improvement in the piracetam group compared with placebo was 3.43 (95 confidence interval (CI) 2.32 to 5.07). Using a fixed-effect model, the OR for improvement with piracetam compared with placebo was 3.55 (95 CI 2.45 to 5.16).Search methods. We searched ALOIS - the Cochrane Dementia and Cognitive Improvement Groups Specialized Register on 4 December 2011 using the terms: piracetam, nootropic, "2-Oxo-1-pyrrolidine Lucetam, Nootropil, Breinox. We identified another review by employees and consultants of the manufacturing company, UCB Pharma (Waegemans 2002) which.

Le rapport des cotes (RC) pour l'amlioration dans le groupe du piractam compar un placebo tait de 3,43 (intervalle de confiance (IC) 95  2,32 5,07). En utilisant un modle effets fixes, le RC pour l'amlioration avec le piractam compar un placebo tait de 3,55 (IC.Top of page Abstract Plain language summary Rsum scientifique. Rsum simplifi Laiki saetak Background Piracetam is a drug that may enhance memory and other intellectual functions, but its usefulness in treating dementia is uncertain.

Data collection and analysis: Two review authors independently extracted data from studies fulfilling the inclusion criteria. We used Intention-to-treat analysis where feasible and pooled studies if appropriate. We planned to perform sensitivity analyses to determine if studies performing poorly on quality criteria affected results.Cette estimation a t tire d'une analyse auprs des personnes ayant achev les tudes plutt que d'une analyse en intention de traiter, car il n'tait pas possible d'extraire les donnes pertinentes des rapports.

En 2002, une.The pharmaceutical company marketing piracetam did not release the results of several unpublished trials. Main results: There were 24 included studies with 11959 participants in total. Many studies were of cross-over design and first-phase data were unavailable, or could not be extracted.